SaxoCell Newsletter Issue No. 3
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June 2022
 

"SaxoPhone" - SaxoCell® Newsletter

In this edition we are portraying another of our platforms: SaxoCellSystems.

We are also looking back at our first Consortium Meeting which provided us with many opportunities of getting to know each other and our projects - no longer online but finally in real!

Last but not least we are reflecting on our first tradeshow visits this year - both in Germany and abroad.

Enjoy reading!
Impressions from Consortium Meeting

Portraying... SaxoCellSystems

News from our projects

NEWS FROM OUR WEBSITE

Save the date - SaxoCell events

News from industry

News from science

past Events

Upcoming events

 

Impressions from our first SaxoCell Consortium Meeting

For the first time since SaxoCell started, most of our members met in real life – not virtually! – to get to know each other, exchange ideas, present initial research results and engage in conversations across all projects and platforms.

Seven months from the kick-off meeting, project leaders, postdocs, PhD students and hub members came together at CRTD in Dresden to represent our young SaxoCell community.

We spent the day presenting data gathered since the cluster kicked off, discussing preliminary results and brainstorming about what’s next. We also created some cheerful project profiles, which facilitated our exchange.

This was a great opportunity to get to know each other better and strategize about how we can develop together when SaxoCell enters its second year of implementation.

We thank everyone for coming and making this day special!
 
» Some photos of the day can be found in our website's members area.
[© SaxoCell; Participants of our 1st SaxoCell Consortium Meeting at the CRTD in Dresden]
 

Portraying...

[© SaxoCell; SYSTEMS]

SaxoCell SYSTEMS

The production of ATMPs on an industrial scale requires automation solutions. Within SaxoCell SYSTEMS, protocols and concepts for automated ATMP production will be developed using machine learning algorithms and novel AI concepts. Additionally, the link to novel quality controls is to be established. The aim is to achieve robust scaling of cell production under GMP conditions for clinical purposes.
 
» Continue reading
 

News from our projects

[© SaxoCell; AlloCART]

AlloCART

AlloCART, the project for the "Preclinical Development of Switchable UniCAR-T as well as UniCAR-Treg" is lead by Martin Bornhäuser and Anke Fuchs and focuses on the development of a serial production of a cell type that suppresses excessive immune responses in healthy humans.
 
» Continue reading

[© SaxoCell; CAR-NK 4.0]

CAR-NK 4.0

This collaboration project – coordinated by Ulrike Köhl – is focusing on the development of a platform technology for the automated manufacturing of allogeneic chimeric antigen receptor natural killer (CAR NK) cells for the treatment of specific cancerous diseases.
 
» Continue reading
 

News from our Website

[© SaxoCell; Website Members Area]
Join the members area on our SaxoCell website

We would like to once more invite you to register on our website's internal members area where we offer
templates for presentations, workshop materials as well as collected information on industry contacts. In addition, our members can access our calendar, previous newsletter editions and participate in our forum.

For registration, please follow the link below.
 
» Link to SaxoCell Members Area
 
» How to access
 

Save the date - SaxoCell trainings and events

June 28th
4:00 - 6:00 PM
Exchange
SaxoCell Stammtisch
Our casual get-together
Ort online / wonder.me
» CLICK HERE TO JOIN
June 30th
9:30 AM - 5:00 PM
Workshop
GMP Training Course
Good Manufacturing Practice basic course
Ort Dresden, CRTD
(Course already fully booked)
July 6th
12:30 - 2:30 PM
Workshop
Technology Transfer Workshop
- Session 2 "How to start up"

Open to all SaxoCell members
Ort Online
» Contact us for registration
July 6th
2:00 - 5:00 PM
Workshop
AI in cancer research and treatment
Bringing together physicians, bioinformaticians and data analysts
Ort Media Campus Villa Ida Leipzig and online
» more information
July 8th
5:00 PM - midnight
Public event
Long Night of Science
Please come and visit our table at CRTD,
near the entrance!
Ort Dresden, CRTD
» more information
July 11th
1:00 - 2:00 PM
Public lecture
Uwe Platzbecker
Immuntherapie bei Blutkrebs - Status und Perspektiven
Ort University Hospital Leipzig UCCL and online
» Register here
August 31st
4:00 - 6:00 PM
Exchange
SaxoCell Stammtisch
Our casual get-together
Ort Leipzig & Dresden
(more information will follow)
September
(details will be announced)
Workshop
Technology Transfer Workshop
- Session 3 "How to cooperate"

Open to all SaxoCell members
Ort Online
» Contact us for registration

[© SaxoCell; Reports]

SaxoCell Cluster Progress Report

In September, we will have to send the first official report on our cluster to the BMBF: the cluster progress report. This report will summarise how the cluster has developed in the first year and it will also provide an outlook to the two years ahead of us.
 
The cluster progress report is an important criterion for the evaluation of the cluster with regard to future funding rounds. The speakers will reflect on the main progress of the cluster, about activities and structures as well as our meeting strategy and different schemes we have created.
 
After one year of SaxoCell, we will be able to see if the original plan is working, where adjustments are needed and what other opportunities have emerged to be filled with new ideas.
 
Even though you and your projects are not directly involved in this report, we would be happy to benefit from your feedback and answers to the questions we will address in August.
 

News from industry

We have compiled an overview on latest news from industry
in the field of gene and cell therapy.
» News from industry
[© SaxoCell; Industry News]
 

News from science

Successful screening of new-born babies at UKD and almost complete resolution of SMA symptoms through early initiation of gene replacement therapy

At UKD, two newborn babies have received gene replacement therapy for spinal muscular atrophy (SMA). Early administration of the drug improves the chances of freedom from symptoms. As part of newborn screening, SMA has been screened for since 1 October 2021.
 
» Continue reading (press release in German)
Related Publications:
Claudia Weiß et al: Gene replacement therapy with onasemnogene abeparvovec in children with spinal muscular atrophy aged 24 months or younger and bodyweight up to 15 kg: an observational cohort study

A. Heinen et al: Seltene chronische und lebenslimitierende Erkrankungen im Kindesalter (Sächsisches Ärzteblatt)

Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension

A report on life-savig therapy for a 3-year-old girl suffering from heavy pulmonary hypertension. Colleagures at MHH hospital in Hanover helped the young patient to recover and now live a normal life.
 
» Continue reading
 

Latest SaxoCell publications

A selection of interesting recent publications from our cluster can be found below:

Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA). Hayden et al., Ann Oncol. 2022 Mar;33(3):259-275.

The era of in vivo T cell engineering. Campos & Hudecek, M.Med (N Y). 2022 Feb 11;3(2):85-86. 

Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma. Merz et al., Nat Commun. 2022 Feb 10;13(1):807. 

Deep learning detects acute myeloid leukemia and predicts NPM1 mutation status from bone marrow smears. Eckardt et al., Leukemia. 2022 Jan;36(1):111-118.

Nanosensors in clinical development of CAR-T cell immunotherapy. Nguyen-Le et al., Biosens Bioelectron. 2022 Jun 15;206:114124.

For the complete list of publications please visit the Members Area of our SaxoCell website.
 
» Please keep us informed!

A selection of other interesting recent publications:

Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer Leidner et al. 
(June 2, 2022)

Engineered cellular immunotherapies in cancer and beyond Finck et al. 
(April 19, 2022)
 

Events – Retrospect

[© SaxoCell; Prof. Dr. Martin Bornhäuser]

Martin Bornhäuser on 'Perspectives of Cell Therapy'

Martin Bornhäuser’s talk on 'Perspectives of Cell Therapy' was a perfect start to the popular science SaxoCell lecture series on cell and gene therapy.

In our hybrid event on April 28th, we welcomed participants at the CRTD and via Zoom. A number of exciting questions followed this interesting talk.

We look forward to many more public SaxoCell lectures and thank Martin Bornhäuser and the participants for kicking off our series.
 
» More information on Martin Bornhäuser

SaxoCell in Barcelona, Hamburg and San Francisco

We are looking back at the major tradeshow highlights in the first half of this year. Join us in looking back at our visits to the ARM Meeting on the Med in Barcelona, the 2022 German Biotechnology Days in Hamburg and the Annual Meeting ISCT 2022 in San Francisco.
 
» Continue reading

BMBF Clusters4Future initiative - exchange of experience in Berlin

Ulrike Köhl, Frank Buchholz and Maren Henneken were on site at the BMBF meeting of Clusters4Future on May 31st in Berlin. It was the first time that all 7 future clusters of the first round met and had the opportunity to talk directly with BMBF and PtJ.
 
The exchange was open, critical and quite solution-oriented. We talked about our experiences at the start of the first implementation phase. It was also exciting to hear where the other clusters stand and what challenges they and their partners have to deal with. Many of them have the same issues as we do, mostly the inflexible budgetary constraints of the PtJ.
 
We learned that the progress report due in September will be evaluated by a jury, so it should be a good piece of self-presentation. Compared to the other clusters, we are doing quite well.
 
ProxiDrug, which is thematically closest to us, would like to organise a joint summer school next year. We very much like this idea and we would like to make use of such synergies!
 
We are very happy about the contacts made. Let's see what other possibilities of cooperation will open up.

[© Steffen Junghanß from Tagesspiegel Fachforum 02.06.2022]

Health Forum of the Tagesspiegel

In June, SaxoCell speakers Ulrike Köhl and Ezio Bonfacio were guests at the Tagesspiegel health forum in Berlin to take a closer look at the current state of cell and gene therapy in Germany.
 
» Watch full event here
 

Events - Preview

Here is a list of upcoming events with SaxoCell participation:
September 12th-14th, 2022
Conference
European School of Haematology (ESH)
2nd Translational Research Conference: Immune & Cellular Therapies: Focus on Advanced Gene-Engineered Immune Cells
Ort Berlin
» to the event
October 12th-14th, 2022
Meeting
BioJapan
Asia’s premier partnering event for the global biotechnology industry
Ort Yokohama, Japan
» to the event
October 24th-26th, 2022
Meeting
BIO-EUROPE 2022
Europe's largest partnering event for the international biotech and pharmaceutical scene
Ort Leipzig, Germany (Hybrid)
» to the event
November 11th, 2022
Meeting
Shaping the future of Medicine
Formerly 'Shaping the future of Hematology'
Ort Leipzig, Germany
» to the event
November 22nd-23rd, 2022
Meeting
LION conference 2022
Leipzig Immune ONcology Conference
Ort Online
» TO THE EVENT
December 10th-13th, 2022
Meeting
64th ASH Annual Meeting and Exposition
American Society for Hematology
Ort New Orleans, USA
» TO THE EVENT

If you are interested in more information about any of these events or about the role of SaxoCell at these tradefairs, please do not hesitate to contact us.
 
» Contact us via e-mail

[© istockphoto]

Outreach activities -- Our call for ideas

Outreach and science communication give us the chance to actively shape the perception of SaxoCell and of the field of cell and gene therapy in general. Therefore, we are looking for ingenious ideas for activities targeting the general public.

Maybe we can create a hands-on activity on “living drugs”, a worksheet for pupils or a web game for the interested public?

Or we have a chat with people in the science tram, in a world café or in a park?

Maybe you would love to give a lecture on your scientific work in public or write a children’s book about it?

The possibilities are unlimited!

If you already are active in science communication, we would be happy to hear what you do, what you like about it and how we could support you with that.

If you are interested to help, but not sure if you have the time or the right idea, please contact us nevertheless and we can figure out a way to support you.
 
» Get in touch with us!

Logo Clusters4Future and Gefördert vom Bundesministerium für Bildung und Forschung
 

Contact us

[© SaxoCell]

We'll be happy to hear from you

If you have any questions, suggestions and feedback regarding the newsletter, please feel free to contact the SaxoCell HUB team.
 
  E-Mail
 
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Responsible for the content of this newsletter:

SaxoCell Hub
SaxoCell® website

BMBF Clusters4Future initiative

Winners of the 2021 BMBF Clusters4Future initiative
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